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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Triamcinolone Acetonide | |
| Synonyms |
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|
| Definitions |
The acetonide salt form of triamcinolone, a synthetic glucocorticosteroid with immunosuppressive and anti-inflammatory activity. Triamcinolone acetonide binds to specific cytosolic glucocorticoid receptors and subsequently interacts with glucocorticoid receptor response element on DNA and alters gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C48027 |
|
| Accepted_Therapeutic_Use_For |
Allergic Rhinitis
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| CAS_Registry |
76-25-5
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|
| Chemical_Formula |
C24H31FO6
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|
| code |
C48027
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|
| Contributing_Source |
FDA
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|
| definition |
The acetonide salt form of triamcinolone, a synthetic glucocorticosteroid with immunosuppressive and anti-inflammatory activity. Triamcinolone acetonide binds to specific cytosolic glucocorticoid receptors and subsequently interacts with glucocorticoid receptor response element on DNA and alters gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished.
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|
| FDA_UNII_Code |
F446C597KA
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| Is_Value_For_GDC_Property | ||
| label |
Triamcinolone Acetonide
|
|
| Legacy Concept Name |
Triamcinolone_Acetonide
|
|
| Maps_To |
Triamcinolone Acetonide
|
|
| NCI_Drug_Dictionary_ID |
649799
|
|
| NSC Number |
21916
|
|
| PDQ_Closed_Trial_Search_ID |
649799
|
|
| PDQ_Open_Trial_Search_ID |
649799
|
|
| Preferred_Name |
Triamcinolone Acetonide
|
|
| prefixIRI |
NCIT:C48027
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|
| prefLabel |
Triamcinolone Acetonide
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| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0040866
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|
| subClassOf |
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