loading...| Preferred Name |
Metronidazole Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C48005 |
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| ALT_DEFINITION |
A drug that is used to treat infection and is being studied in the treatment of cancer. It is type of antibacterial, antiprotozoal, and anthelmintic. |
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| CAS_Registry |
69198-10-3 |
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| CHEBI_ID |
CHEBI:50687 |
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| Chemical_Formula |
C6H9N3O3.HCl |
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| code |
C48005 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. |
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| FDA_UNII_Code |
76JC1633UF |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Metronidazole Hydrochloride |
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| Legacy Concept Name |
Metronidazole_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
39503 |
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| PDQ_Closed_Trial_Search_ID |
39503 |
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| PDQ_Open_Trial_Search_ID |
39503 |
|
| Preferred_Name |
Metronidazole Hydrochloride |
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| prefixIRI |
NCIT:C48005 |
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| prefLabel |
Metronidazole Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0282239 |
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| subClassOf |