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Biological and Environmental Research Ontology
| Preferred Name | Methylprednisolone Sodium Succinate | |
| Synonyms |
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| Definitions |
The sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C48004 |
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| CAS_Registry |
2375-03-3
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| Chemical_Formula |
C26H33O8.Na
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| code |
C48004
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| Contributing_Source |
CTRP FDA
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| definition |
The sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
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| Display_Name |
Methylprednisolone Sodium Succinate
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| FDA_UNII_Code |
LEC9GKY20K
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 |
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| Is_Value_For_GDC_Property | ||
| label |
Methylprednisolone Sodium Succinate
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| Legacy Concept Name |
Methylprednisolone_Sodium_Succinate
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| Maps_To |
Methylprednisolone Sodium Succinate
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| NSC Number |
48989
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| Preferred_Name |
Methylprednisolone Sodium Succinate
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| prefixIRI |
NCIT:C48004
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| prefLabel |
Methylprednisolone Sodium Succinate
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0700546
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| subClassOf |
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