loading...| Preferred Name |
Lidocaine Hydrochloride |
|
| Synonyms |
|
|
| Definitions |
The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C48000 |
|
| CAS_Registry |
6108-05-0 |
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| CHEBI_ID |
CHEBI:60791 |
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| Chemical_Formula |
C14H22N2O.HCl.H2O |
|
| code |
C48000 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. |
|
| Display_Name |
Lidocaine Hydrochloride |
|
| FDA_UNII_Code |
V13007Z41A |
|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Lidocaine Hydrochloride |
|
| Legacy Concept Name |
Lidocaine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
39607 |
|
| PDQ_Closed_Trial_Search_ID |
39607 |
|
| PDQ_Open_Trial_Search_ID |
39607 |
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| Preferred_Name |
Lidocaine Hydrochloride |
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| prefixIRI |
NCIT:C48000 |
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| prefLabel |
Lidocaine Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0546869 |
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| subClassOf |