loading...| Preferred Name |
Diclofenac Sodium |
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| Synonyms |
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| Definitions |
The sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47984 |
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| Accepted_Therapeutic_Use_For |
Osteoarthritis; Ophthalmic Inflammation |
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| ALT_DEFINITION |
A drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent. |
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| CAS_Registry |
15307-79-6 |
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| CHEBI_ID |
CHEBI:4509 |
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| Chemical_Formula |
C14H10Cl2NO2.Na |
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| code |
C47984 |
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| Contributing_Source |
FDA |
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| definition |
The sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. |
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| FDA_UNII_Code |
QTG126297Q |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Diclofenac Sodium |
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| Legacy Concept Name |
Diclofenac_Sodium |
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| NCI_Drug_Dictionary_ID |
792632 |
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| PDQ_Closed_Trial_Search_ID |
792632 |
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| PDQ_Open_Trial_Search_ID |
792632 |
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| Preferred_Name |
Diclofenac Sodium |
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| prefixIRI |
NCIT:C47984 |
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| prefLabel |
Diclofenac Sodium |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700583 |
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| subClassOf |