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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Chlorhexidine Gluconate | |
| Synonyms |
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| Definitions |
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47974 |
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| CAS_Registry |
18472-51-0
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| CHEBI_ID |
CHEBI:28312
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| Chemical_Formula |
C22H30Cl2N10.2C6H12O7
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|
| code |
C47974
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| Contributing_Source |
CTRP FDA
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|
| definition |
The gluconate salt form of chlorhexidine, a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine gluconate is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine gluconate penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
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| Display_Name |
Chlorhexidine Gluconate
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|
| FDA_UNII_Code |
MOR84MUD8E
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Chlorhexidine Gluconate
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| Legacy Concept Name |
Chlorhexidine_Gluconate
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| NCI_Drug_Dictionary_ID |
747732
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| PDQ_Closed_Trial_Search_ID |
747732
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|
| PDQ_Open_Trial_Search_ID |
747732
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| Preferred_Name |
Chlorhexidine Gluconate
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| prefixIRI |
NCIT:C47974
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| prefLabel |
Chlorhexidine Gluconate
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0055361
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| subClassOf |
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