Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Cefazolin Sodium | |
| Synonyms |
|
|
| Definitions |
The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47968 |
|
| CAS_Registry |
27164-46-1
|
|
| CHEBI_ID |
CHEBI:3483
|
|
| Chemical_Formula |
C14H13N8O4S3.Na
|
|
| code |
C47968
|
|
| Contributing_Source |
FDA
|
|
| definition |
The sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis.
|
|
| FDA_UNII_Code |
P380M0454Z
|
|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Cefazolin Sodium
|
|
| Legacy Concept Name |
Cefazolin_Sodium
|
|
| NCI_Drug_Dictionary_ID |
640180
|
|
| NSC Number |
291561
|
|
| PDQ_Closed_Trial_Search_ID |
640180
|
|
| PDQ_Open_Trial_Search_ID |
640180
|
|
| Preferred_Name |
Cefazolin Sodium
|
|
| prefixIRI |
NCIT:C47968
|
|
| prefLabel |
Cefazolin Sodium
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0700526
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping