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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Zolmitriptan | |
| Synonyms |
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|
| Definitions |
A member of the triptan class of agents with anti-migraine properties. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47789 |
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| CAS_Registry |
139264-17-8
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| CHEBI_ID |
CHEBI:10124
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| Chemical_Formula |
C16H21N3O2
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|
| code |
C47789
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|
| Contributing_Source |
FDA
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|
| definition |
A member of the triptan class of agents with anti-migraine properties. Zolmitriptan selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and central terminals in brainstem sensory nuclei. Receptor binding results in constriction of cranial vessels, reduction of vessel pulsation and inhibition of nociceptive transmission, thereby providing relief of migraine headaches. Zolmitriptan may also relieve migraine headaches by inhibition of pro-inflammatory neuropeptide release.
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| FDA_UNII_Code |
2FS66TH3YW
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|
| in_subset | ||
| label |
Zolmitriptan
|
|
| Legacy Concept Name |
Zolmitriptan
|
|
| NCI_Drug_Dictionary_ID |
779011
|
|
| PDQ_Closed_Trial_Search_ID |
779011
|
|
| PDQ_Open_Trial_Search_ID |
779011
|
|
| Preferred_Name |
Zolmitriptan
|
|
| prefixIRI |
NCIT:C47789
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|
| prefLabel |
Zolmitriptan
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0528166
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| subClassOf |
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