Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Tirofiban Hydrochloride
Synonyms
Definitions

The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.
ID

http://purl.obolibrary.org/obo/NCIT_C47759
CAS_Registry

150915-40-5
CHEBI_ID

CHEBI:9606
Chemical_Formula

C22H36N2O5S.HCl.H2O
code

C47759
Contributing_Source

FDA
definition

The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time.
FDA_UNII_Code

6H925F8O5J
Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C76405
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Tirofiban Hydrochloride
Legacy Concept Name

Tirofiban_Hydrochloride
Preferred_Name

Tirofiban Hydrochloride
prefixIRI

NCIT:C47759
prefLabel

Tirofiban Hydrochloride
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C0795668
subClassOf

http://purl.obolibrary.org/obo/NCIT_C1327
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