loading...| Preferred Name |
Tirofiban Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47759 |
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| CAS_Registry |
150915-40-5 |
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| CHEBI_ID |
CHEBI:9606 |
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| Chemical_Formula |
C22H36N2O5S.HCl.H2O |
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| code |
C47759 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride salt form of tirofiban, a non-peptide tyrosine derivative with anticoagulant property. Tirofiban antagonizes fibrinogen binding to the platelet cell surface receptor, glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. The antagonism prevents adenylyl cyclase activation, which mediated via GP IIb/IIIa receptor complex, and results in decreased levels of cAMP and thereby interferes with platelet membrane function and subsequent platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time. |
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| FDA_UNII_Code |
6H925F8O5J |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Tirofiban Hydrochloride |
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| Legacy Concept Name |
Tirofiban_Hydrochloride |
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| Preferred_Name |
Tirofiban Hydrochloride |
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| prefixIRI |
NCIT:C47759 |
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| prefLabel |
Tirofiban Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0795668 |
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| subClassOf |