loading...| Preferred Name |
Procainamide Hydrochloride |
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| Synonyms |
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| Definitions |
The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47687 |
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| CAS_Registry |
614-39-1 |
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| CHEBI_ID |
CHEBI:8429 |
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| Chemical_Formula |
C13H21N3O.HCl |
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| code |
C47687 |
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| Contributing_Source |
FDA |
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| definition |
The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction. |
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| FDA_UNII_Code |
SI4064O0LX |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Procainamide Hydrochloride |
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| Legacy Concept Name |
Procainamide_Hydrochloride |
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| NSC Number |
27461 |
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| Preferred_Name |
Procainamide Hydrochloride |
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| prefixIRI |
NCIT:C47687 |
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| prefLabel |
Procainamide Hydrochloride |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0600311 |
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| subClassOf |