Preferred Name

Oxiconazole Nitrate

Synonyms
Definitions

The nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.

ID

http://purl.obolibrary.org/obo/NCIT_C47644

CAS_Registry

64211-46-7

Chemical_Formula

C18H13Cl4N3O.HNO3

code

C47644

Contributing_Source

FDA

definition

The nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth.

FDA_UNII_Code

RQ8UL4C17S

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C61869

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

label

Oxiconazole Nitrate

Legacy Concept Name

Oxiconazole_Nitrate

Preferred_Name

Oxiconazole Nitrate

prefixIRI

NCIT:C47644

prefLabel

Oxiconazole Nitrate

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0142160

subClassOf

http://purl.obolibrary.org/obo/NCIT_C514

Delete Subject Author Type Created
No notes to display