loading...| Preferred Name |
Olmesartan Medoxomil |
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| Synonyms |
|
|
| Definitions |
A synthetic imidazole derivative prodrug with an antihypertensive property. Upon hydrolysis, olmesartan medoxomil is converted to olmesartan. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor of angiotensin II in vascular smooth muscle and adrenal gland, thereby competing angiotensin II binding to the receptor. This prevents angiotensin II-induced vasoconstriction and decreases aldosterone production, thereby preventing aldosterone-stimulated sodium retention and potassium excretion. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47640 |
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| CAS_Registry |
144689-63-4 |
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| Chemical_Formula |
C29H30N6O6 |
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| code |
C47640 |
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| Contributing_Source |
FDA |
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| definition |
A synthetic imidazole derivative prodrug with an antihypertensive property. Upon hydrolysis, olmesartan medoxomil is converted to olmesartan. Olmesartan selectively binds to the angiotensin type 1 (AT1) receptor of angiotensin II in vascular smooth muscle and adrenal gland, thereby competing angiotensin II binding to the receptor. This prevents angiotensin II-induced vasoconstriction and decreases aldosterone production, thereby preventing aldosterone-stimulated sodium retention and potassium excretion. |
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| FDA_UNII_Code |
6M97XTV3HD |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
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| label |
Olmesartan Medoxomil |
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| Legacy Concept Name |
Olmesartan_Medoxomil |
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| Preferred_Name |
Olmesartan Medoxomil |
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| prefixIRI |
NCIT:C47640 |
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| prefLabel |
Olmesartan Medoxomil |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0386393 |
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| subClassOf |