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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Mebendazole | |
| Synonyms |
|
|
| Definitions |
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47595 |
|
| CAS_Registry |
31431-39-7
|
|
| CHEBI_ID |
CHEBI:6704
|
|
| Chemical_Formula |
C16H13N3O3
|
|
| code |
C47595
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death.
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|
| Display_Name |
Mebendazole
|
|
| FDA_UNII_Code |
81G6I5V05I
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Mebendazole
|
|
| Legacy Concept Name |
Mebendazole
|
|
| NCI_Drug_Dictionary_ID |
743306
|
|
| NSC Number |
184849
|
|
| PDQ_Closed_Trial_Search_ID |
743306
|
|
| PDQ_Open_Trial_Search_ID |
743306
|
|
| Preferred_Name |
Mebendazole
|
|
| prefixIRI |
NCIT:C47595
|
|
| prefLabel |
Mebendazole
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0025023
|
|
| subClassOf |
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