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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Loracarbef | |
| Synonyms |
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| Definitions |
A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47588 |
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| CAS_Registry |
121961-22-6
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| Chemical_Formula |
C16H16ClN3O4.H2O
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| code |
C47588
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| Contributing_Source |
FDA
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|
| definition |
A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents.
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| FDA_UNII_Code |
3X11EVM5SU
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| in_subset | ||
| label |
Loracarbef
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|
| Legacy Concept Name |
Loracarbef
|
|
| Preferred_Name |
Loracarbef
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| prefixIRI |
NCIT:C47588
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| prefLabel |
Loracarbef
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0721422
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| subClassOf |
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