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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Isosorbide Mononitrate | |
| Synonyms |
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| Definitions |
The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47575 |
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| CAS_Registry |
16051-77-7
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| CHEBI_ID |
CHEBI:6062
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| Chemical_Formula |
C6H9NO6
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| code |
C47575
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| Contributing_Source |
FDA
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| definition |
The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
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| FDA_UNII_Code |
LX1OH63030
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Isosorbide Mononitrate
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| Legacy Concept Name |
Isosorbide_Mononitrate
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| Preferred_Name |
Isosorbide Mononitrate
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| prefixIRI |
NCIT:C47575
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| prefLabel |
Isosorbide Mononitrate
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0064079
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| subClassOf |
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