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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Fondaparinux Sodium | |
| Synonyms |
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| Definitions |
The sodium salt form of fondaparinux, a synthetic glucopyranoside with antithrombotic activity. Fondaparinux sodium selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. (NCI05) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47539 |
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| ALT_DEFINITION |
A drug used to prevent blood clots from forming inside blood vessels in the leg. It is being studied in the prevention of blood clots in some cancer patients, including women having surgery for cancer of the reproductive tract. It is a type of anticoagulant.
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| CAS_Registry |
114870-03-0
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| CHEBI_ID |
CHEBI:31632
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| Chemical_Formula |
C31H43N3O49S8.10Na
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| code |
C47539
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| Contributing_Source |
CTRP FDA
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|
| definition |
The sodium salt form of fondaparinux, a synthetic glucopyranoside with antithrombotic activity. Fondaparinux sodium selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. (NCI05)
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| Display_Name |
Fondaparinux Sodium
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| FDA_UNII_Code |
X0Q6N9USOZ
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| label |
Fondaparinux Sodium
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| Legacy Concept Name |
Fondaparinux_Sodium
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| NCI_Drug_Dictionary_ID |
510285
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| PDQ_Closed_Trial_Search_ID |
510285
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| PDQ_Open_Trial_Search_ID |
510285
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| Preferred_Name |
Fondaparinux Sodium
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| prefixIRI |
NCIT:C47539
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| prefLabel |
Fondaparinux Sodium
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C1099664
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| subClassOf |
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