loading...| Preferred Name |
Flumazenil |
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| Synonyms |
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| Definitions |
An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47534 |
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| CAS_Registry |
78755-81-4 |
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| CHEBI_ID |
CHEBI:5103 |
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| Chemical_Formula |
C15H14FN3O3 |
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| code |
C47534 |
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| Contributing_Source |
FDA |
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| definition |
An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. |
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| FDA_UNII_Code |
40P7XK9392 |
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| in_subset | ||
| label |
Flumazenil |
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| Legacy Concept Name |
Flumazenil |
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| Preferred_Name |
Flumazenil |
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| prefixIRI |
NCIT:C47534 |
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| prefLabel |
Flumazenil |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0016293 |
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| subClassOf |