Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Ezetimibe | |
| Synonyms |
|
|
| Definitions |
An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47529 |
|
| CAS_Registry |
163222-33-1
|
|
| CHEBI_ID |
CHEBI:49040
|
|
| Chemical_Formula |
C24H21F2NO3
|
|
| code |
C47529
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
An azetidinone derivative and a cholesterol absorption inhibitor with lipid-lowering activity. Ezetimibe appears to interact physically with cholesterol transporters at the brush border of the small intestine and inhibits the intestinal absorption of cholesterol and related phytosterols. As a result, ezetimibe causes a decrease in the level of blood cholesterol or an increase in the clearance of cholesterol from the bloodstream. Overall, the following effects observed are a reduction of hepatic cholesterol stores and a reduction of total cholesterol, LDL cholesterol, and other triglycerides in the blood.
|
|
| Display_Name |
Ezetimibe
|
|
| FDA_UNII_Code |
EOR26LQQ24
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Ezetimibe
|
|
| Legacy Concept Name |
Ezetimibe
|
|
| NCI_Drug_Dictionary_ID |
754008
|
|
| PDQ_Closed_Trial_Search_ID |
754008
|
|
| PDQ_Open_Trial_Search_ID |
754008
|
|
| Preferred_Name |
Ezetimibe
|
|
| prefixIRI |
NCIT:C47529
|
|
| prefLabel |
Ezetimibe
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C1142985
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping