Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
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Preferred Name

Ergotamine Tartrate
Synonyms
Definitions

The tartrate salt form of ergotamine, an ergot alkaloid and adrenergic alpha agonist with vasoconstrictor activity. Ergotamine tartrate selectively binds to alpha-adrenergic receptors thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins. Ergotamine tartrate also blocks serotonin 5-HT1D receptors, thereby also causing vasoconstriction in cerebral blood vessels. Constriction of cerebral blood vessels caused by this agent may reduce the blood flow and pressure in cerebral arteries and may relieve the pain of vascular headaches.
ID

http://purl.obolibrary.org/obo/NCIT_C47517
CAS_Registry

24381-56-4

379-79-3
Chemical_Formula

2C33H35N5O5.C4H6O6
code

C47517
Contributing_Source

FDA
definition

The tartrate salt form of ergotamine, an ergot alkaloid and adrenergic alpha agonist with vasoconstrictor activity. Ergotamine tartrate selectively binds to alpha-adrenergic receptors thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins. Ergotamine tartrate also blocks serotonin 5-HT1D receptors, thereby also causing vasoconstriction in cerebral blood vessels. Constriction of cerebral blood vessels caused by this agent may reduce the blood flow and pressure in cerebral arteries and may relieve the pain of vascular headaches.
FDA_UNII_Code

MRU5XH3B48
Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C61751
in_subset

http://purl.obolibrary.org/obo/NCIT_C63923
label

Ergotamine Tartrate
Legacy Concept Name

Ergotamine_Tartrate
NSC Number

41869
Preferred_Name

Ergotamine Tartrate
prefixIRI

NCIT:C47517
prefLabel

Ergotamine Tartrate
Semantic_Type

Pharmacologic Substance
UMLS_CUI

C2936189
subClassOf

http://purl.obolibrary.org/obo/NCIT_C47794

http://purl.obolibrary.org/obo/NCIT_C29709
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