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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Dofetilide | |
| Synonyms |
|
|
| Definitions |
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C47499 |
|
| CAS_Registry |
115256-11-6
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|
| CHEBI_ID |
CHEBI:4681
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|
| Chemical_Formula |
C19H27N3O5S2
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|
| code |
C47499
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|
| Contributing_Source |
FDA
|
|
| definition |
A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
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|
| FDA_UNII_Code |
R4Z9X1N2ND
|
|
| in_subset | ||
| label |
Dofetilide
|
|
| Legacy Concept Name |
Dofetilide
|
|
| Preferred_Name |
Dofetilide
|
|
| prefixIRI |
NCIT:C47499
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|
| prefLabel |
Dofetilide
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|
| Semantic_Type |
Pharmacologic Substance
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|
| UMLS_CUI |
C0114771
|
|
| subClassOf |
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