loading...| Preferred Name |
Dihydroergotamine Mesylate |
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| Synonyms |
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| Definitions |
An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C47491 |
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| CAS_Registry |
6190-39-2 |
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| CHEBI_ID |
CHEBI:59756 |
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| Chemical_Formula |
C33H37N5O5.CH4O3S |
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| code |
C47491 |
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| Contributing_Source |
FDA |
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| definition |
An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release. |
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| FDA_UNII_Code |
81AXN7R2QT |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Dihydroergotamine Mesylate |
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| Legacy Concept Name |
Dihydroergotamine_Mesylate |
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| Preferred_Name |
Dihydroergotamine Mesylate |
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| prefixIRI |
NCIT:C47491 |
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| prefLabel |
Dihydroergotamine Mesylate |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700532 |
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| subClassOf |