Preferred Name |
Domperidone |
|
Synonyms |
|
|
Definitions |
A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C454 |
|
CAS_Registry |
57808-66-9 |
|
CHEBI_ID |
CHEBI:31515 |
|
Chemical_Formula |
C22H24ClN5O2 |
|
code |
C454 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders. |
|
Display_Name |
Domperidone |
|
FDA_UNII_Code |
5587267Z69 |
|
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
label |
Domperidone |
|
Legacy Concept Name |
Domperidone |
|
NCI_Drug_Dictionary_ID |
40071 |
|
NSC Number |
299589 |
|
PDQ_Closed_Trial_Search_ID |
40071 |
|
PDQ_Open_Trial_Search_ID |
40071 |
|
Preferred_Name |
Domperidone |
|
prefixIRI |
NCIT:C454 |
|
prefLabel |
Domperidone |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0013015 |
|
subClassOf |