loading...| Preferred Name | Zalcitabine | |
| Synonyms |
|
|
| Definitions |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C430 |
|
| CAS_Registry |
7481-89-2 |
|
| CHEBI_ID |
CHEBI:10101 |
|
| Chemical_Formula |
C9H13N3O3 |
|
| code |
C430 |
|
| Contributing_Source |
FDA |
|
| definition |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04) |
|
| FDA_UNII_Code |
6L3XT8CB3I |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
|
| Is_Value_For_GDC_Property | ||
| label |
Zalcitabine |
|
| Legacy Concept Name |
Zalcitabine |
|
| Maps_To |
Zalcitabine |
|
| NCI_Drug_Dictionary_ID |
40349 |
|
| NSC Number |
606170 |
|
| PDQ_Closed_Trial_Search_ID |
40349 |
|
| PDQ_Open_Trial_Search_ID |
40349 |
|
| Preferred_Name |
Zalcitabine |
|
| prefixIRI |
NCIT:C430 |
|
| prefLabel |
Zalcitabine |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0012132 |
|
| subClassOf |