loading...| Preferred Name |
Dexamethasone |
|
| Synonyms |
|
|
| Definitions |
A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C422 |
|
| Accepted_Therapeutic_Use_For |
Allergic disorders; antiemetic; corneal injury; inflammatory conditions |
|
| ALT_DEFINITION |
A synthetic steroid (similar to steroid hormones produced naturally in the adrenal gland). Dexamethasone is used to treat leukemia and lymphoma and may be used to treat some of the problems caused by other cancers and their treatment. |
|
| CAS_Registry |
50-02-2 |
|
| CHEBI_ID |
CHEBI:41879 |
|
| Chemical_Formula |
C22H29FO5 |
|
| code |
C422 |
|
| Contributing_Source |
CTRP DIPG/DMG FDA PCDC |
|
| definition |
A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04) |
|
| Display_Name |
Dexamethasone |
|
| FDA_UNII_Code |
7S5I7G3JQL |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 http://purl.obolibrary.org/obo/NCIT_C183082 http://purl.obolibrary.org/obo/NCIT_C183083 |
|
| Is_Value_For_GDC_Property | ||
| label |
Dexamethasone |
|
| Legacy Concept Name |
Dexamethasone |
|
| Maps_To |
Dexamethasone |
|
| NCI_Drug_Dictionary_ID |
39789 |
|
| NSC Number |
34521 |
|
| PDQ_Closed_Trial_Search_ID |
39789 |
|
| PDQ_Open_Trial_Search_ID |
39789 |
|
| Preferred_Name |
Dexamethasone |
|
| prefixIRI |
NCIT:C422 |
|
| prefLabel |
Dexamethasone |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0011777 |
|
| subClassOf |