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Biological and Environmental Research Ontology
| Preferred Name | Dapsone | |
| Synonyms |
|
|
| Definitions |
A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C415 |
|
| Accepted_Therapeutic_Use_For |
Acne vulgaris; Dermatitis herpetiformis; Leprosy
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|
| ALT_DEFINITION |
A drug used to treat acne. It is also used to treat other types of skin diseases and certain bacterial infections, such as leprosy. It blocks bacteria from making a substance that they need to grow. Dapsone is a type of antibacterial agent and a type of anti-inflammatory agent.
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| CAS_Registry |
80-08-0
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|
| CHEBI_ID |
CHEBI:4325
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|
| Chemical_Formula |
C12H12N2O2S
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|
| code |
C415
|
|
| Contributing_Source |
FDA
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|
| definition |
A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.
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| FDA_UNII_Code |
8W5C518302
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|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 |
|
| label |
Dapsone
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|
| Legacy Concept Name |
Dapsone
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| NCI_Drug_Dictionary_ID |
40323
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|
| NSC Number |
6091
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| PDQ_Closed_Trial_Search_ID |
40323
|
|
| PDQ_Open_Trial_Search_ID |
40323
|
|
| Preferred_Name |
Dapsone
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|
| prefixIRI |
NCIT:C415
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|
| prefLabel |
Dapsone
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
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|
| UMLS_CUI |
C0010980
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| subClassOf |
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