loading...| Preferred Name |
6-Aminonicotinamide |
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| Synonyms |
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| Definitions |
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C38127 |
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| CAS_Registry |
329-89-5 |
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| code |
C38127 |
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| Contributing_Source |
FDA |
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| definition |
A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04) |
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| FDA_UNII_Code |
D6FNW67F2B |
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| in_subset | ||
| label |
6-Aminonicotinamide |
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| Legacy Concept Name |
_6-Aminonicotinamide |
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| NSC Number |
21206 |
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| Preferred_Name |
6-Aminonicotinamide |
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| prefixIRI |
NCIT:C38127 |
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| prefLabel |
6-Aminonicotinamide |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0000610 |
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| subClassOf |