loading...| Preferred Name | Cenersen | |
| Synonyms |
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| Definitions |
A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C37454 |
|
| CAS_Registry |
415168-49-9 |
|
| code |
C37454 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
A phosphorothioate oligonucleotide harboring nucleotide sequences complementary to tumor suppressor p53 mRNA. Cenersen hybridizes with p53 mRNA molecules, and induces Rnase H dependent hydrolysis of p53 transcripts in the double stranded section of the hybrids, thereby resulting in loss of p53 production. Loss of p53 activity leads to sensitization of cancer cells to other therapeutics. |
|
| Display_Name |
Cenersen |
|
| FDA_UNII_Code |
K6KJ8AZ05F |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Cenersen |
|
| Legacy Concept Name |
EL625 |
|
| Maps_To |
Cenersen |
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| NCI_Drug_Dictionary_ID |
354249 |
|
| PDQ_Closed_Trial_Search_ID |
354249 |
|
| PDQ_Open_Trial_Search_ID |
354249 |
|
| Preferred_Name |
Cenersen |
|
| prefixIRI |
NCIT:C37454 |
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| prefLabel |
Cenersen |
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| Semantic_Type |
Pharmacologic Substance |
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| UMLS_CUI |
C0700610 |
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| subClassOf |