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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Chlorhexidine | |
| Synonyms |
|
|
| Definitions |
A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C364 |
|
| CAS_Registry |
55-56-1
|
|
| CHEBI_ID |
CHEBI:3614
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|
| Chemical_Formula |
C22H30Cl2N10
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|
| code |
C364
|
|
| Contributing_Source |
CTRP FDA
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|
| definition |
A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.
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|
| Display_Name |
Chlorhexidine
|
|
| FDA_UNII_Code |
R4KO0DY52L
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|
| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Chlorhexidine
|
|
| Legacy Concept Name |
Chlorhexidine
|
|
| NCI_Drug_Dictionary_ID |
41544
|
|
| PDQ_Closed_Trial_Search_ID |
41544
|
|
| PDQ_Open_Trial_Search_ID |
41544
|
|
| Preferred_Name |
Chlorhexidine
|
|
| prefixIRI |
NCIT:C364
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|
| prefLabel |
Chlorhexidine
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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|
| UMLS_CUI |
C0008196
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|
| subClassOf |
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