Preferred Name |
Cefotaxime |
|
Synonyms |
|
|
Definitions |
A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C354 |
|
CAS_Registry |
63527-52-6 |
|
CHEBI_ID |
CHEBI:204928 |
|
Chemical_Formula |
C16H17N5O7S2 |
|
code |
C354 |
|
Contributing_Source |
FDA |
|
definition |
A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. |
|
FDA_UNII_Code |
N2GI8B1GK7 |
|
Has_Salt_Form | ||
in_subset | ||
label |
Cefotaxime |
|
Legacy Concept Name |
Cefotaxime |
|
NCI_Drug_Dictionary_ID |
39177 |
|
PDQ_Closed_Trial_Search_ID |
39177 |
|
PDQ_Open_Trial_Search_ID |
39177 |
|
Preferred_Name |
Cefotaxime |
|
prefixIRI |
NCIT:C354 |
|
prefLabel |
Cefotaxime |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
UMLS_CUI |
C0007554 |
|
subClassOf |