loading...| Preferred Name |
Carmustine |
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| Synonyms |
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| Definitions |
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C349 |
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| Accepted_Therapeutic_Use_For |
Brain tumors; colon cancer; lung cancer; lymphomas; Hodgkins and Non-Hodgkins; melanoma; multiple myeloma; mycosis fungoides |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called alkylating agents. |
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| CAS_Registry |
154-93-8 |
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| CHEBI_ID |
CHEBI:3423 |
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| Chemical_Formula |
C5H9Cl2N3O2 |
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| code |
C349 |
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| Contributing_Source |
CTRP FDA PCDC |
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| definition |
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04) |
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| Display_Name |
Carmustine |
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| FDA_UNII_Code |
U68WG3173Y |
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C186341 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 http://purl.obolibrary.org/obo/NCIT_C186327 http://purl.obolibrary.org/obo/NCIT_C186328 |
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| Is_Value_For_GDC_Property | ||
| label |
Carmustine |
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| Legacy Concept Name |
Carmustine |
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| Maps_To |
Carmustine |
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| NCI_Drug_Dictionary_ID |
43027 |
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| NSC Number |
409962 |
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| PDQ_Closed_Trial_Search_ID |
43027 |
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| PDQ_Open_Trial_Search_ID |
43027 |
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| Preferred_Name |
Carmustine |
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| prefixIRI |
NCIT:C349 |
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| prefLabel |
Carmustine |
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| Semantic_Type |
Pharmacologic Substance Hazardous or Poisonous Substance |
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| UMLS_CUI |
C0007257 |
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| subClassOf |