loading...| Preferred Name |
Bleomycin Sulfate |
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| Synonyms |
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| Definitions |
A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C312 |
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| Accepted_Therapeutic_Use_For |
Squamous cell carcinomas of the head and neck; penis; cervix and vulva; Hodgkins and; non-Hodgkins lymphoma; testicular embryonal cell and ovarian carcinoma; chorio- and teratocarcinoma; malignant pleural effusion; melanoma; sarcoma; ovary germ cell tumor |
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| ALT_DEFINITION |
A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Blenoxane that damages DNA and may kill cancer cells. It is a type of antineoplastic antibiotic. |
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| CAS_Registry |
9041-93-4 |
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| CHEBI_ID |
CHEBI:34582 |
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| code |
C312 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from Streptomyces verticillus. Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
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| Display_Name |
Bleomycin Sulfate |
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| FDA_UNII_Code |
7DP3NTV15T |
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Bleomycin Sulfate |
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| Legacy Concept Name |
Bleomycin_Sulphate |
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| Maps_To |
Bleomycin Sulfate |
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| NCI_Drug_Dictionary_ID |
39139 |
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| PDQ_Closed_Trial_Search_ID |
39139 |
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| PDQ_Open_Trial_Search_ID |
39139 |
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| Preferred_Name |
Bleomycin Sulfate |
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| prefixIRI |
NCIT:C312 |
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| prefLabel |
Bleomycin Sulfate |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Antibiotic |
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| UMLS_CUI |
C0005739 |
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| subClassOf |