loading...| Preferred Name |
Type I Hypersensitivity |
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| Synonyms |
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| Definitions |
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C3116 |
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| ALT_DEFINITION |
An immunoglobulin E (IgE) mediated hypersensitivity reaction. These usually occur within an hour of exposure to an allergen. |
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| code |
C3116 |
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| Contributing_Source |
MedDRA NICHD |
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| definition |
Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue. |
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| in_subset | ||
| label |
Type I Hypersensitivity |
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| Legacy Concept Name |
Immediate_Hypersensitivity |
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| Maps_To |
Immediate hypersensitivity reaction |
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| Preferred_Name |
Type I Hypersensitivity |
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| prefixIRI |
NCIT:C3116 |
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| prefLabel |
Type I Hypersensitivity |
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| Semantic_Type |
Disease or Syndrome |
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| UMLS_CUI |
C0020523 |
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| subClassOf |