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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Terfenadine | |
| Synonyms |
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| Definitions |
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29494 |
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| CAS_Registry |
50679-08-8
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| Chemical_Formula |
C32H41NO2
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|
| code |
C29494
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| Contributing_Source |
FDA
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| definition |
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways.
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| FDA_UNII_Code |
7BA5G9Y06Q
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| in_subset | ||
| label |
Terfenadine
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| Legacy Concept Name |
Terfenadine
|
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| NSC Number |
665802
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| Preferred_Name |
Terfenadine
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|
| prefixIRI |
NCIT:C29494
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| prefLabel |
Terfenadine
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0085173
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| subClassOf |
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