loading...| Preferred Name |
Terfenadine |
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| Synonyms |
|
|
| Definitions |
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29494 |
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| CAS_Registry |
50679-08-8 |
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| Chemical_Formula |
C32H41NO2 |
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| code |
C29494 |
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| Contributing_Source |
FDA |
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| definition |
A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways. |
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| FDA_UNII_Code |
7BA5G9Y06Q |
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| in_subset | ||
| label |
Terfenadine |
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| Legacy Concept Name |
Terfenadine |
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| NSC Number |
665802 |
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| Preferred_Name |
Terfenadine |
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| prefixIRI |
NCIT:C29494 |
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| prefLabel |
Terfenadine |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0085173 |
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| subClassOf |