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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Tazarotene | |
| Synonyms |
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| Definitions |
A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29487 |
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| Accepted_Therapeutic_Use_For |
Topical treatment of facial acne vulgaris; stable plaque psoriasis; mitigation (palliation) of facial fine wrinkling; facial mottled hyper- and hypopigmentation; benign facial lentigines
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| ALT_DEFINITION |
A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Tazarotene is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Tazarotene is a type of synthetic retinoid.
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| CAS_Registry |
118292-40-3
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| CHEBI_ID |
CHEBI:32184
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| Chemical_Formula |
C21H21NO2S
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| code |
C29487
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| Contributing_Source |
CTRP FDA
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| definition |
A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)
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| Display_Name |
Tazarotene
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| FDA_UNII_Code |
81BDR9Y8PS
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| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Tazarotene
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| Legacy Concept Name |
Tazarotene
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| Maps_To |
Tazarotene
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| NCI_Drug_Dictionary_ID |
553530
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| PDQ_Closed_Trial_Search_ID |
553530
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| PDQ_Open_Trial_Search_ID |
553530
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| Preferred_Name |
Tazarotene
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| prefixIRI |
NCIT:C29487
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| prefLabel |
Tazarotene
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0288792
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| subClassOf |
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