loading...| Preferred Name | Salmeterol | |
| Synonyms |
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|
| Definitions |
A highly selective, long-acting beta-2 adrenergic agonist with bronchodilatory activity. Salmeterol's benzene moiety resembles the structure of catecholamines, and occupies the active site of beta-2 adrenergic receptor, while the long, lipophilic side chain of salmeterol, binds to the so called 'exosite' near the beta-2 adrenergic receptors. The binding at the exosite allows the active portion of the molecule to remain at the receptor site and continually engage and disengage with the receptor, therefore providing a long duration of action. This agent stimulates intracellular adenyl cyclase to catalyze the conversion of adenosine triphosphate to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels result in relaxation of bronchiolar smooth muscle, bronchodilation and increased bronchial airflow. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C29443 |
|
| CAS_Registry |
89365-50-4 |
|
| CHEBI_ID |
CHEBI:9011 |
|
| Chemical_Formula |
C25H37NO4 |
|
| code |
C29443 |
|
| Contributing_Source |
FDA |
|
| definition |
A highly selective, long-acting beta-2 adrenergic agonist with bronchodilatory activity. Salmeterol's benzene moiety resembles the structure of catecholamines, and occupies the active site of beta-2 adrenergic receptor, while the long, lipophilic side chain of salmeterol, binds to the so called 'exosite' near the beta-2 adrenergic receptors. The binding at the exosite allows the active portion of the molecule to remain at the receptor site and continually engage and disengage with the receptor, therefore providing a long duration of action. This agent stimulates intracellular adenyl cyclase to catalyze the conversion of adenosine triphosphate to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels result in relaxation of bronchiolar smooth muscle, bronchodilation and increased bronchial airflow. |
|
| FDA_UNII_Code |
2I4BC502BT |
|
| Has_Salt_Form | ||
| in_subset | ||
| label |
Salmeterol |
|
| Legacy Concept Name |
Salmeterol |
|
| Preferred_Name |
Salmeterol |
|
| prefixIRI |
NCIT:C29443 |
|
| prefLabel |
Salmeterol |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0073992 |
|
| subClassOf |