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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Quinine Sulfate | |
| Synonyms |
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| Definitions |
The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29399 |
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| CAS_Registry |
207671-44-1
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| CHEBI_ID |
CHEBI:52250
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| Chemical_Formula |
2C20H24N2O2.2H2O.H2SO4
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| code |
C29399
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| Contributing_Source |
FDA
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| definition |
The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
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| FDA_UNII_Code |
KF7Z0E0Q2B
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Quinine Sulfate
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| Legacy Concept Name |
Quinine_Sulfate
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| NSC Number |
5362 667852
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| Preferred_Name |
Quinine Sulfate
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| prefixIRI |
NCIT:C29399
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| prefLabel |
Quinine Sulfate
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0034422
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| subClassOf |
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