Preferred Name

Pentamidine Isethionate
Synonyms
Definitions

A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C29349

ALT_DEFINITION

A drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.

CAS_Registry

140-64-7

CHEBI_ID

CHEBI:7977

Chemical_Formula

C19H24N4O2.2C2H6O4S

code

C29349

Contributing_Source

FDA

definition

A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04)

FDA_UNII_Code

V2P3K60DA2

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C731

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C176424

label

Pentamidine Isethionate

Legacy Concept Name

Pentamidine_Isethionate

NCI_Drug_Dictionary_ID

778947

NSC Number

620107

PDQ_Closed_Trial_Search_ID

778947

PDQ_Open_Trial_Search_ID

778947

Preferred_Name

Pentamidine Isethionate

prefixIRI

NCIT:C29349

prefLabel

Pentamidine Isethionate

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0030864

subClassOf

http://purl.obolibrary.org/obo/NCIT_C514

http://purl.obolibrary.org/obo/NCIT_C277

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