Preferred Name

Milrinone Lactate

Synonyms
Definitions

A bipyridine agent with positive inotropic and vasodilator properties. Milrinone lactate selectively inhibits fraction III cyclic adenosine monophosphate (cAMP) phosphodiesterase isozymes in the heart and vascular muscles, thereby increasing cAMP and, consequently, an increase in cAMP-dependent intracellular ionized calcium and myocardium contractile force, and vasodilation in arteriolar and venous vascular smooth muscle. This agent improves hemodynamics in patients with ventricular dysfunction by increasing the stroke volume index and left ventricular contractility and by producing pulmonary vasodilation. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C29263

CAS_Registry

100286-97-3

CHEBI_ID

CHEBI:34850

Chemical_Formula

C12H9N3O.C3H6O3

code

C29263

Contributing_Source

FDA

definition

A bipyridine agent with positive inotropic and vasodilator properties. Milrinone lactate selectively inhibits fraction III cyclic adenosine monophosphate (cAMP) phosphodiesterase isozymes in the heart and vascular muscles, thereby increasing cAMP and, consequently, an increase in cAMP-dependent intracellular ionized calcium and myocardium contractile force, and vasodilation in arteriolar and venous vascular smooth muscle. This agent improves hemodynamics in patients with ventricular dysfunction by increasing the stroke volume index and left ventricular contractility and by producing pulmonary vasodilation. (NCI04)

FDA_UNII_Code

9K8XR81MO8

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C61848

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

label

Milrinone Lactate

Legacy Concept Name

Milrinone_Lactate

Preferred_Name

Milrinone Lactate

prefixIRI

NCIT:C29263

prefLabel

Milrinone Lactate

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0600487

subClassOf

http://purl.obolibrary.org/obo/NCIT_C744

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