Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Metoprolol Succinate | |
| Synonyms |
|
|
| Definitions |
The succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol succinate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C29254 |
|
| CAS_Registry |
98418-47-4
|
|
| Chemical_Formula |
2C15H25NO3.C4H6O4
|
|
| code |
C29254
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
The succinate salt form of metoprolol, a cardioselective competitive beta-1 adrenergic receptor antagonist with antihypertensive properties and devoid of intrinsic sympathomimetic activity. Metoprolol succinate antagonizes beta 1-adrenergic receptors in the myocardium, thereby reducing the rate and force of myocardial contraction, and consequently a diminished cardiac output. This agent may also reduce the secretion of renin with subsequent reduction in levels of angiotensin II thus decreasing sympathetic activation, including vasoconstriction, aldosterone secretion.
|
|
| Display_Name |
Metoprolol Succinate
|
|
| FDA_UNII_Code |
TH25PD4CCB
|
|
| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Metoprolol Succinate
|
|
| Legacy Concept Name |
Metoprolol_Succinate
|
|
| NCI_Drug_Dictionary_ID |
809245
|
|
| Preferred_Name |
Metoprolol Succinate
|
|
| prefixIRI |
NCIT:C29254
|
|
| prefLabel |
Metoprolol Succinate
|
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance
|
|
| UMLS_CUI |
C0724633
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping