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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Lansoprazole | |
| Synonyms |
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| Definitions |
A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C29150 |
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| CAS_Registry |
103577-45-3
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|
| CHEBI_ID |
CHEBI:6375
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| Chemical_Formula |
C16H14F3N3O2S
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|
| code |
C29150
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| Contributing_Source |
FDA
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|
| definition |
A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.
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| FDA_UNII_Code |
0K5C5T2QPG
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|
| in_subset | ||
| label |
Lansoprazole
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|
| Legacy Concept Name |
Lansoprazole
|
|
| NCI_Drug_Dictionary_ID |
483101
|
|
| PDQ_Closed_Trial_Search_ID |
483101
|
|
| PDQ_Open_Trial_Search_ID |
483101
|
|
| Preferred_Name |
Lansoprazole
|
|
| prefixIRI |
NCIT:C29150
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|
| prefLabel |
Lansoprazole
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0050940
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| subClassOf |
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