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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Ketamine Hydrochloride | |
| Synonyms |
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| Definitions |
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29142 |
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| ALT_DEFINITION |
A drug used to cause a loss of feeling and awareness and to induce sleep in patients having surgery. It is also being studied in the treatment of nerve pain caused by chemotherapy. Ketalar blocks pathways to the brain that are involved in sensing pain. It is a type of general anesthetic.
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| CAS_Registry |
1867-66-9
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| CHEBI_ID |
CHEBI:650657
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| Chemical_Formula |
C13H16ClNO.HCl
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| code |
C29142
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| Contributing_Source |
CPTAC CTRP FDA
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|
| definition |
The hydrochloride salt of a synthetic derivative of cyclohexanone with analgesic and anesthetic activities. Although its mechanism of action is not well understood, ketamine appears to non-competitively block N-methyl-D-aspartate (NMDA) receptors and may interact with opioid mu receptors and sigma receptors, thereby reducing pain perception, inducing sedation, and producing dissociative anesthesia.
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| Display_Name |
Ketamine Hydrochloride
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| FDA_UNII_Code |
O18YUO0I83
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C156952 http://purl.obolibrary.org/obo/NCIT_C156953 http://purl.obolibrary.org/obo/NCIT_C116977 |
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| label |
Ketamine Hydrochloride
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| Legacy Concept Name |
Ketamine_Hydrochloride
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| NCI_Drug_Dictionary_ID |
452041
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| PDQ_Closed_Trial_Search_ID |
452041
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| PDQ_Open_Trial_Search_ID |
452041
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| Preferred_Name |
Ketamine Hydrochloride
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| prefixIRI |
NCIT:C29142
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| prefLabel |
Ketamine Hydrochloride
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0700541
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| subClassOf |
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