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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Isosorbide Dinitrate | |
| Synonyms |
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| Definitions |
The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05) |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C29134 |
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| CAS_Registry |
87-33-2
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| CHEBI_ID |
CHEBI:6061
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| Chemical_Formula |
C6H8N2O8
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| code |
C29134
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| Contributing_Source |
FDA
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| definition |
The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
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| FDA_UNII_Code |
IA7306519N
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset | ||
| label |
Isosorbide Dinitrate
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| Legacy Concept Name |
Isosorbide_Dinitrate
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| NSC Number |
80038
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| Preferred_Name |
Isosorbide Dinitrate
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| prefixIRI |
NCIT:C29134
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| prefLabel |
Isosorbide Dinitrate
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| Semantic_Type |
Organic Chemical Pharmacologic Substance
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| UMLS_CUI |
C0022252
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| subClassOf |
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