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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Hydroxyzine | |
| Synonyms |
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| Definitions |
A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C29103 |
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| CAS_Registry |
68-88-2
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| CHEBI_ID |
CHEBI:5818
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| Chemical_Formula |
C21H27ClN2O2
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|
| code |
C29103
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| Contributing_Source |
FDA
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|
| definition |
A piperazine derivative with antihistamine, antiemetic, and anxiolytic properties. Hydroxyzine's antihistaminic effect is due to its metabolite, cetirizine, a potent H1 receptor antagonist and selective inhibitor of peripheral H1 receptors. This agent competes with histamine for binding at H1-receptor sites on the effector cell surface. The sedative properties of hydroxyzine occur as a result of suppression of certain subcortical regions of the brain. Secondary to its central anticholinergic actions, hydroxyzine may be effective as an antiemetic.
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| FDA_UNII_Code |
30S50YM8OG
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| Has_Salt_Form | ||
| in_subset | ||
| label |
Hydroxyzine
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|
| Legacy Concept Name |
Hydroxyzine
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| NSC Number |
169188
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| Preferred_Name |
Hydroxyzine
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| prefixIRI |
NCIT:C29103
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| prefLabel |
Hydroxyzine
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C0020404
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| subClassOf |
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