loading...| Preferred Name | Azathioprine | |
| Synonyms |
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|
| Definitions |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C290 |
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| CAS_Registry |
446-86-6 |
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| CHEBI_ID |
CHEBI:2948 |
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| Chemical_Formula |
C9H7N7O2S |
|
| code |
C290 |
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| Contributing_Source |
FDA GDC |
|
| definition |
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. |
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| FDA_UNII_Code |
MRK240IY2L |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 |
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| Is_Value_For_GDC_Property | ||
| label |
Azathioprine |
|
| Legacy Concept Name |
Azathioprine |
|
| Maps_To |
Azathioprine |
|
| NSC Number |
39084 |
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| Preferred_Name |
Azathioprine |
|
| prefixIRI |
NCIT:C290 |
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| prefLabel |
Azathioprine |
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| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
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| UMLS_CUI |
C0004482 |
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| subClassOf |