loading...| Preferred Name |
Clobetasol Propionate |
|
| Synonyms |
|
|
| Definitions |
The propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C28934 |
|
| Accepted_Therapeutic_Use_For |
Psoriasis, Eczema |
|
| CAS_Registry |
25122-46-7 |
|
| CHEBI_ID |
CHEBI:31414 |
|
| Chemical_Formula |
C25H32ClFO5 |
|
| code |
C28934 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
The propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2. |
|
| Display_Name |
Clobetasol Propionate |
|
| FDA_UNII_Code |
779619577M |
|
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Clobetasol Propionate |
|
| Legacy Concept Name |
Clobetasol_Propionate |
|
| NCI_Drug_Dictionary_ID |
547027 |
|
| PDQ_Closed_Trial_Search_ID |
547027 |
|
| PDQ_Open_Trial_Search_ID |
547027 |
|
| Preferred_Name |
Clobetasol Propionate |
|
| prefixIRI |
NCIT:C28934 |
|
| prefLabel |
Clobetasol Propionate |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0055895 |
|
| subClassOf |