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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Cefoxitin Sodium | |
| Synonyms |
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| Definitions |
The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C28915 |
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| CAS_Registry |
33564-30-6
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| Chemical_Formula |
C16H16N3O7S2.Na
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| code |
C28915
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| Contributing_Source |
CTRP FDA
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| definition |
The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
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| Display_Name |
Cefoxitin Sodium
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| FDA_UNII_Code |
Q68050H03T
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
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| label |
Cefoxitin Sodium
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| Legacy Concept Name |
Cefoxitin_Sodium
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| NCI_Drug_Dictionary_ID |
787118
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| PDQ_Closed_Trial_Search_ID |
787118
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| PDQ_Open_Trial_Search_ID |
787118
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| Preferred_Name |
Cefoxitin Sodium
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| prefixIRI |
NCIT:C28915
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| prefLabel |
Cefoxitin Sodium
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0700446
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| subClassOf |
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