Preferred Name | Cefazolin | |
Synonyms |
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|
Definitions |
A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C28913 |
|
CAS_Registry |
25953-19-9 |
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CHEBI_ID |
CHEBI:474053 |
|
Chemical_Formula |
C14H14N8O4S3 |
|
code |
C28913 |
|
Contributing_Source |
CTRP FDA |
|
definition |
A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
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Display_Name |
Cefazolin |
|
FDA_UNII_Code |
IHS69L0Y4T |
|
Has_Salt_Form | ||
in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
label |
Cefazolin |
|
Legacy Concept Name |
Cefazolin |
|
Preferred_Name |
Cefazolin |
|
prefixIRI |
NCIT:C28913 |
|
prefLabel |
Cefazolin |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
UMLS_CUI |
C0007546 |
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subClassOf |