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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | Cefazolin | |
| Synonyms |
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| Definitions |
A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C28913 |
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| CAS_Registry |
25953-19-9
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| CHEBI_ID |
CHEBI:474053
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| Chemical_Formula |
C14H14N8O4S3
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|
| code |
C28913
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| Contributing_Source |
CTRP FDA
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|
| definition |
A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
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| Display_Name |
Cefazolin
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|
| FDA_UNII_Code |
IHS69L0Y4T
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 |
|
| label |
Cefazolin
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|
| Legacy Concept Name |
Cefazolin
|
|
| Preferred_Name |
Cefazolin
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|
| prefixIRI |
NCIT:C28913
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| prefLabel |
Cefazolin
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| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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| UMLS_CUI |
C0007546
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| subClassOf |
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