Preferred Name

Verapamil Hydrochloride
Synonyms
Definitions

The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

ID

http://purl.obolibrary.org/obo/NCIT_C2827

CAS_Registry

152-11-4

CHEBI_ID

CHEBI:53188

Chemical_Formula

C27H38N2O4.ClH

code

C2827

Contributing_Source

CTRP

FDA

definition

The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

Display_Name

Verapamil Hydrochloride

FDA_UNII_Code

V3888OEY5R

Has_Free_Acid_Or_Base_Form

http://purl.obolibrary.org/obo/NCIT_C928

in_subset

http://purl.obolibrary.org/obo/NCIT_C63923

http://purl.obolibrary.org/obo/NCIT_C116977

http://purl.obolibrary.org/obo/NCIT_C116978

label

Verapamil Hydrochloride

Legacy Concept Name

Verapamil_Hydrochloride

NSC Number

272366

657799

Preferred_Name

Verapamil Hydrochloride

prefixIRI

NCIT:C2827

prefLabel

Verapamil Hydrochloride

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0700468

subClassOf

http://purl.obolibrary.org/obo/NCIT_C333

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