loading...| Preferred Name | Eribulin Mesylate | |
| Synonyms |
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| Definitions |
The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C26644 |
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| Accepted_Therapeutic_Use_For |
unresectable or metastatic liposarcoma; breast cancer |
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| ALT_DEFINITION |
A drug used to treat metastatic breast cancer in patients who have already been treated with other chemotherapy. It is also being studied in the treatment of other types of cancer. Halaven may block cancer cell growth by stopping cell division. It belongs to the family of drugs called antitubulin agents. |
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| CAS_Registry |
253128-41-5 |
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| Chemical_Formula |
C40H59NO11.CH4O3S |
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| code |
C26644 |
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| Contributing_Source |
CTRP FDA |
|
| definition |
The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. |
|
| Display_Name |
Eribulin Mesylate |
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| FDA_UNII_Code |
AV9U0660CW |
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| Has_Free_Acid_Or_Base_Form | ||
| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Eribulin Mesylate |
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| Legacy Concept Name |
E7389 |
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| Maps_To |
Eribulin Mesylate |
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| NCI_Drug_Dictionary_ID |
257773 |
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| NSC Number |
707389 |
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| PDQ_Closed_Trial_Search_ID |
257773 |
|
| PDQ_Open_Trial_Search_ID |
257773 |
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| Preferred_Name |
Eribulin Mesylate |
|
| prefixIRI |
NCIT:C26644 |
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| prefLabel |
Eribulin Mesylate |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C2608038 |
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| subClassOf |