loading...| Preferred Name | Ipilimumab | |
| Synonyms |
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| Definitions |
A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. |
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| ID |
http://purl.obolibrary.org/obo/NCIT_C2654 |
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| Accepted_Therapeutic_Use_For |
Unresectable or Metastatic Melanoma |
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| ALT_DEFINITION |
A monoclonal antibody being studied in the treatment of certain types of cancer. Ipilimumab is made in the laboratory and binds to the molecule CTLA-4 on T cells (a type of white blood cell). Ipilimumab may block CTLA-4 and help the immune system kill cancer cells. |
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| CAS_Registry |
477202-00-9 |
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| code |
C2654 |
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| Contributing_Source |
CTRP FDA |
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| definition |
A recombinant human immunoglobulin (Ig) G1 monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), with immune checkpoint inhibitory and antineoplastic activities. Ipilimumab binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. |
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| Display_Name |
Ipilimumab |
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| FDA_UNII_Code |
6T8C155666 |
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| Has_Target | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C116977 http://purl.obolibrary.org/obo/NCIT_C116978 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Ipilimumab |
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| Legacy Concept Name |
Anti-Cytotoxic_T-Lymphocyte-Associated_Antigen-4_Monoclonal_Antibody |
|
| Maps_To |
Ipilimumab |
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| NCI_Drug_Dictionary_ID |
38447 |
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| NSC Number |
720801 732442 |
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| PDQ_Closed_Trial_Search_ID |
38447 |
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| PDQ_Open_Trial_Search_ID |
38447 |
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| Preferred_Name |
Ipilimumab |
|
| prefixIRI |
NCIT:C2654 |
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| prefLabel |
Ipilimumab |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor |
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| UMLS_CUI |
C1367202 |
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| subClassOf |